I suggest a halliburton briefcase with numerous security measures. Fingerprint scan, a security code that resets after each use...I'm quite partial to these on my travels. Can't tell you how many times they've saved my rear.
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I have a nice diane von furstenberg laptop bag. I got it at marshalls though, so I can't give any suggestions on where to find it. Target had a isaac mizrahi one that i was considering too. i used to have a nine west one, but since i got a larger lap top i had to get the diane von furstenberg one.
I have a coach briefcase and I love it. Most of them would fit a laptop and i believe they might even have a specific briefcase with a section for a laptop. You should check the website (coach.com).