Thanks! The suggestions have been great. Wineries sound fun, but I'd rather go to DL any day

Even better, the Haunted Mansion holiday overlay will be up and running while we're there! I've always wanted to see WDW decorated for the holidays, but I'll take a little bit of DL instead!
So, after much discussion and some feedback from a coworker of DH's who says we'd be insane to drive in and out of Anaheim (hurrah!) here's the final and booked plan:
San Diego Friday & Saturday
Pick up rental car and head to Anaheim Saturday night through Monday
Back to SD Monday night
Fly home Tuesday
Now if I could just figure out what I'm going to do on Friday afternoon/evening I'd be set! Yes, I'm leaning towards shopping and dinner somewhere. Now I'm really weird and can't stand Mexican food. (I know, you all have given me these great suggestions and I hate mexican food!) Also for AKAMonet, my husband does not thank you for telling me there's a Tiffany's right there