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We used to give Ace to one of our dogs before taking car trips. It wasn't really because she was aggressive, but the poor thing just wouldn't calm down. Everything got her worked up. When we told our vet about it, he suggested giving her Ace before putting her in the car. She has since calmed down, and we no longer need to drug her before trips, but having that Ace was priceless. (Our dog is a Border/Aussie mix - weighs around 50lbs - and a $10 bottle of Ace lasted quite a while. Granted, we didn't put her in the car everyday, so yours probably wouldn't last as long, but for us the cost was pretty minimal.)
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