If there's a health related problem I'd suggest referring to a doctor. S/he can tell them to lose weight.
But i still see nothing wrong with talking to a close friend/sister about it. Especially if it's an indicator of more serious issues.
Overweight people KNOW they're overweight. But they don't necessarily know that someone's there for them. It's the same reason you give someone your support for any other major life issue.
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