CutiePie2000
Well, I guess I can be your authority on Fresno, seeing as I was born and lived there for 18 years

(whats more, my mom works in the medical community!)
I can give you the basics, and if you want more info, go right on ahead and contact me.
PrincessHeather was right about the weather, it can get damn hot there in the summers (up to 115 or 120!). In the winter, tempatures drop to the high 20s/low 30s.
The population within city limits is probably up to about 500,000 but if you count the surrounding areas, it's up to about 850,000. Fresno often has this reputation of being a small, rural, farming town but this is not true at all. Agriculture is still predominant in the area, but parts of Fresno are like any other city. Particularly in North Fresno (where I lived), where there is an abundance of restaurants, shopping, and other things to do (plus, you can get a great view of the Sierra Mountains)
As any city, there is a certain part of town that is pretty rough, but there are plenty of places that are well kept, clean & safe. I'm not sure what was going on when other GC'ers visited and had bottles thrown at them, but Fresno State is located there and the students do get a little rowdy when it comes to their athletics (but it is limited to that).
For California, the price of living is very good. Whereas in the Bay Area you can expect the median price of a house to be about $350,000, you can get something of comparable quality in Fresno for less than $200,000.
In addition, Fresno's location in California is pretty good. It's about 3 1/2 hours from LA and 2 1/2 from San Francisco. 2 hours to the beach, 1 1/2 hours to the mountains (1 hr to Yosemite!)
It's a great place to raise a family, I have often thought about returning there to do just that (even after having lived in Southern CA, on the beach, and now in the SF Bay Area). I spent 18 years wanting to get out, but now when I go back I see it wasn't such a horrible place and always have a great time when I am there.
Out of curiousity, which hospital had offered her a job??
Hope this helps!!!