Depends what you want to do, what you like to do and how old you are.
Just for fun, I'd say stop off in Long Beach and hit the Aquarium of the Pacific, it's really cool if you are into that sort of thing.
Sea World is cool, but way over priced now.
Pacific Beach in SD is nice, and the Gaslamp area in SD is nice too.
What do you like to do? I can give better suggestions based on your interests. =)
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