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Soooo... I got off Depo because I was gaining weight and figured since I wasn't dating, what was the point.
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I'm on Depo and a huge fan. However, I've heard of really bad reactions to the birth control method and that everyone has really varied reactions to the shot. My doctor let me know that I should not start the method unless I was committed to it. He also let me know that statiscally, I would probably gain 10 pounds. It took a year for the spotting to stop (one week of spotting four weeks after I got the shot) but now, just the other week, I remembered that I have not had menstral cramps for two years. And before I started, he let me know that after I stopped the injections, it was going to take a full year before my cycle returned to normal. I have a great reaction to the medicine and its really easy to take the time to get the shot four times a year - it forces me to take a half day from work and enjoy a morning!
And I didn't gain any weight. But from gossip I've heard from friends, I think my positive reaction to the birth control was a little uncommon.