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I read this bit of speculation on TWOP. FWIW:
The human remains in the box are that of either a baby sitter or younger "sibling." Zach, the Young kid murdered either one of them when little (perhaps by accident... or maybe he's just twisted). MA collapsed under pressure and killed herself because her husband was covering it up. And Plumber Mike/FBI dude is either looking for the babysitter remains, or perhaps his late wife and he had a child and it was a playmate of Zach's... or something.
I added a little more to it but that's what I'm thinking...
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