This is a great thread.
Some of my ex-boyfriend's fraternity brothers used to sit around and chug Nyquil. That was some messed up stuff. They seriously acted like they were on K or something. I'll take Nyquil if I'm sick, but I'm no fan of its taste.
I rather like Jagerbombs. I've never had a shot of straight Jager (that I can remember...)

Maybe on my 21st?
One of my finest moments was this summer when this guy at the bar decided we all needed to drink Jagerbombs. We had like 3 in a row or something. I think I had to end up finishing his for him.... Everyone was like "Whoooaaaa there." BWA HAHA.
Sadly, now I am poor and in class and have neither time or money to go to the bar.