Thinking of checking out the follwoing when they eventually come out (don't know about soon):
Evil Genius - I've always liked Dr. Evil
Hearts of Iron 2 - should be a better WW2 simulation
Immortal Cities: Children of the Nile - a much improved Pharoh
Pirates! - loved the original years ago...
The Fall: The Last Days of Gaia - sorta like Fallout but 3D
Ghost Recon 2 - first was good, this should be even better
VtM: Bloodlines - always enjoyed the pen & paper game
Xenus - looks like a cool RPG FPS combination