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Hit Central West End, Laclede's Landing, The Loop, or Wesport. I recommend Westport because it is the safest. All three areas have a variety of bars and clubs. The Loop is a more artsy area, if you're into that kind of environment. However, if you're staying downtown Central West End and Laclede's landing is a lot closer than Westport, which is in a town called "Maryland Heights".
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