Eh, it's no biggie. I've flown to my hometown (not far from JAX) from Atlanta--by the time you get to cruising altitude, you're only up there for about 20 minutes before you start your approach into ATL.
I didn't fly much before starting college--a few trips annually to see friends and relatives. But, since Mom and Daddy are in FL, and I went to school in RI, I got used to flying a lot.