Ybor is safe if you ask me - I was just there on Saturday for Gasparilla!
If you're going on a cruise you're going to be down at Channelside and there are some really cool place down there to go to. Here's the list: (21 & over)
1. Stumps Supper Club and Howl @ The Moon - pay 1 price to get into both. Stumps has great food and drinks and Howl @ The Moon id the dueling piano bar and TONS of fun.
2. Margaritta Momma's and Bannana Joes - again you pay 1 price to get into both. Bananna Joes is the club part and has great music and a great crowd.
3. Splitsville - it's an upscale bowling alley. TONS OF FUN!
You can then take the trolly from Channelside down to Ybor and here are my picks in Ybor:
1.Coyote Ugly - yep, just like the movie and a whole lotta fun
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2. Amplitheatre - upscale and expensive but GOOD drinks and a rotating dance floor!
3. Twilight - same as Amp but no rotating dance floor.
If you have any other questions, just ask. From where you hotel is to Channelside and Ybor is like a 10/15 min drive just because of all the traffic lights!
Have fun!