I am facing the same thing. I've been here 10 years and its gonna be hard. I am considering it partly for the same reasons you are, and also becasue I am in a relationship with someone who will be moving to another are of the country and if things progress, theres a good chance I will be going with.
As a fellow graphic designer (print, not web) you gotta consider the impact an area will have on your carrear. I dotn knwo if you are wanting to get a goig with an in house design dept, liek for a big company, or with a firm or ad agency, but where you go will affect your choices. San Antonio sucks for design. In Texas you have to be in Dallas or Houston. There was some work in Austin, but its not what it was. I have also heard great things about Miami, Atlanta, NYC, Minneapolis, Boston and Philly as well as Seattle and obviously San Fran. I'd suggest contacting someone at AIGA (American Institute of Graphic Arts -
www.aiga.org ) to get their feedback, 'cause ya gotta consider your career.
Good luck, whatever you do.