Be prepared for hot and sticky weather! And/or rain
You probably won't be doing this but I'd prefer to stay in a bed and breakfast than a regular hotel. We did and we loved it. It was a block off of the main road but very quiet.
And Hilton Head is just up the road!
If you had time, you could go down to down to Ft. Frederica and St. Simons, where the first "Georgians" landed. The Methodist Church was founded at Christ Church..outside of St. Simons. It is very beautiful and peaceful there.