It really depends on the interviewer. Some folks will still fall for that "weakness that is really a strength" thing, but most folks recognize if for what it is. What may work better is to take a true weakness and say what you have done, are doing to overcome it. "I've found that my writing is still very college/essay oriented instead of business oriented. Now, when I write memos I make sure I go through them with a fine tooth comb to edit our unnessary words and phrases." or something like that.
Another note, most large companies are now using behavioral or situational interviews and do not ask questions like "strengths and weaknesses." They want to know what you have done in the past, so they will ask questions like
"Tell me about a time where you had to take a leadership role in a project."
"Tell me about a time when you had to resolve a conflict with a coworker or a classmate."
Walk me through the steps you take to organize your day/self.
While it is common to pause before you answer these types of questions (most people need to think of an example), it would probably be helpful for you to think of some of your shining moments at previous jobs or school so you will be prepared. Good luck!