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My father, grandfather and great aunt were bipolar. As far as I know there is no cure and my father takes lithium and about 10 other different medications plus sees a psychiatrist. Even though I am not bipolar I am afraid I may pass it along in my genes and thus probably won't have children (maybe adopt?). It is a very difficult disease to live with as a family member.
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I think if you have children and any depression is in your family history, I would just setup the necessary support sytems If they showed signs of having it. My dad has it and Im still going to have children.