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As a flight attendant, I can share several tips with you that I have found to be helpful, and also some things I have witnessed that are not. Try to sleep on the flight over, but remember flying is very dehydrating, so do not use alcohol to lull you into sleep and definitely do not mix sleep plissé and alcohol...you do not even want to hear the stories I could tell on that one. Speaking of sleeping pills, I do not encourage their use at all unless you are currently using them and know how you react. If you feel it may be an issue, I would recommend a 'simply sleep' option or melatonin. You really shouldn't need them unless you already have sleep issues.
Be careful about consuming too much salt, etc. before or during the flight due to dehydration.
If you must imbibe, remember alcohol affects the body inflight much differently. 1 drink equals 2, and it can get embarrassing quickly.
Use noise canceling headsets (you can get these online for a decent price).
Get on schedule as quickly as possible. Stay up when you arrive until a decent bed time. This should help your sleep cycle.
If you get to the Nottinghill area, eating at Churchill's is a must! Great Thai food in the back of a very beautiful, traditional British Pub.
Tell your bank you will be traveling, so no charges are blocked.
If you have an iPhone, imessaging is free from phone to phone in wifi area (as is FaceTime). Otherwise, sign up for magic jack or viber. (Other users must have viber to receive calls).
Use your credit/ATM card to get money while you are there. You get the best rate this way. Many banks charge a small fee, so consider that so you don't have too many transactions.
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