Well... everywhere in Iowa is in the middle of nowhere
seriously though, Muscatine is in the eastern half of Iowa - about a half hour from Iowa City (where the University of Iowa is) it's really close to the Iowa/Illinois border - probably 15 minutes. It's also probably about a half hour from the Quad Cities... I've never been there, so I can't tell you much about it! You'd be only about 2.5 hours from Chicago, 4/5 hrs from the Twin Cities, and 4 hrs from St. Louis...