Depends on how much I win. If I only win $5, that won't go very far.
Assuming I win a multi-million-dollar jackpot:
1. Pay off my mortgage, car loans, and DH's student loans.
2. Make some charitable donations, particularly to my synagogue.
3. Take off with DH for six weeks or so, and travel the world.
4. Build an addition onto our house - maybe a solarium.
5. Invest the rest.