The problem is, we really don't know what it's going to do. It may end up being no big deal at all, but better safe than sorry, right? The variants have become more and more complex. It's a pretty fascinating worm for us IT geeks. The theories are that it's likely to go after big corporate systems in search of mass numbers of credit card numbers, social security numbers, etc. for financial gain.
ETA: For all we know, it's going to send out a pop up that says "April Fools!"