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For the 'average' user, Windows Defender is probably the best AV option - I know, MS sucks, but they bought it from someone else. It's very, very good, although moderately resource-intensive (and it plugs right into OneCare, which is quite promising). The price is right, too.
Past that, you should be running some sort of spyware suite - I run scans from malwarebytes, plus run SnoopFree in the background to prevent keyboard hooking.
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