After years of writing MLA style for Art History and the Humanities, I had to learn APA just to edit my husband's undergraduate psychology papers. APA is much easier. The upshot of this is that when I go to grad school next fall, I am prepared to write either way because I will be applying for interdisciplinary type programs.
Here's a question -- isn't Chicago style just a longer, more formal version of MLA? I know that some of my papers have included some Chicago style formatting. I used to write completely out of Kate Turabian's handbook and it is still my standby reference volume for any formal academic writing. However, I am also aware that things have changed since I first started writing in the mid-seventies.