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With Prader Willi Syndrome, the child has a reduced need for calories. The really cruel part of the disease is not only do fewer calories make them fat, but they also have a flaw in the hypothalamus which make them constantly hungry. They never feel full. They have a continuous need to eat.
No appetite suppresant has been found effective in this disease. They have to be kept on an extremely low calorie diet just to stay at a normal weight.. and parents have sometimes resorted to having to lock the cabinets and refrigerators.
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