I don't think I could live in cities in the middle of America, or anywhere too far north (too cold!) ... I could live places on the West Coast, in states along the southern border, and in the South.
I really hated Detroit the times I've passed through it, but maybe I just missed the good parts (?). Odessa, TX, is one of the nastiest smelling and ugliest looking places I've ever been, although everywhere else I've been in Texas has been nice. I've been pretty freaked out by visits to some Southern cities where segregation is still pretty firmly in place - people glared at me in Mobile because I apparently crossed the color line by asking the wrong person for restaurant recommendations
My favorite city is DC. Atlanta is probably second favorite. Still lots more to visit, tho'