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Sometimes spyware starts it's evil doings on Start up. So restarting your compy can just make things worse. I forget what you run... I believe it's MsConfig and there is a way to stop programs from loading at start up. It'll give you a list of things that do. If you find some funky stuff, uncheck it all and hit save. (Start Menu>Run...> msconfig)
I had to do this with my friend's computer... I unplugged her cable line. That way anything needing to obtain an internet connection to produce pop ups couldn't. Then I ran all her virus scans and whatnot.
Worst case scenario, you reinstall Windows to wipe everything. But that's after you've tried everything to no avail.
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