This actually happened to my grandmother. Her and my grandfather tried for years to have children, but couldn't. So they decided to adopt my father and his sister, about four years later she became pregnant with my uncle.
My grandparents never really showed any of the kids tons of affection, I think this is a product of them both having nannies raise them then my dad having the same, but the favoritism is apparent that my granmother shows for my uncle. My grandfather was not like this though.
This is mostly why my dad felt like his aunt was more of a mother figure to him, she took care of him and took him to do things more than my grandmother did once another boy came along. My aunt was still the only girl though.
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