ADPhi Amherst had 51 firre alarms in 3 yrs.
 

Amherst denies fraternity permit - Building owner plans to appeal ...
Daily Hampshire Gazette (subscription),_MA_- Sep 9, 2005

... The Amherst Fire Department has been called to Alpha Delta Phi at 382 North Pleasant St. 51 times in 2003, 2004 and the first six of 2005

(Don't know what the rest of the story is - they want $$$ to see it)

I'd bet any money that the Pitt Pikes and SigEps would beat that record (it's sort of a duplex-ish set up), at least when I was in college. Pretty much anytime the other was having a party, someone would pull the alarm. I didn't even go up there very often but i've had to stand outside in the cold on multiple occasions.