- Chronic progressive granulomatous infection of skin and subcutaneous tissue, usually of
extremities.
- Mostly in Central and South America.
- Infection by direct implantation of organisms found in decaying vegetation.
- The raised, crusted, verrucous lesions involve a granulomatous host response to the fungus.
- Small, round, thick-walled, brown “sclerotic bodies” can be seen histopathologically.

- Rare, slowly progressive infection of skin and subcutaneous tissue.
- Generally affects extremities, buttocks, face.
- Localized to Amazon region and other parts of Central and South America.
- Causative agent has not been cultured, but may be identified histopathologically as round
or oval cells in short chains in dermis.
- Genomic analyses indicate close relatedness to

- Chronic infection characterized by large nasal and other mucosal polyps.
- Localized to Asia, South America, and Africa.
- Causative agent has not been cultured, but may be identified histopathologically as
resembling an endosporulating fungus.
- Taxonomic classification has not been definitively established. Rather than a fungus, it